高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (6): 1028.

• 研究快报 • 上一篇    下一篇

分子印迹SiO2纳米管膜的制备及其生化分离应用

张淑琼1, 杨黄浩2, 庄峙厦1,2, 王小如1,2   

  1. 1. 现代分析科学教育部重点实验室, 厦门大学化学系, 厦门 361005;
    2. 国家海洋局第一海洋研究所物质迁移与反应机理实验室, 青岛 266061
  • 收稿日期:2003-12-09 出版日期:2004-06-24 发布日期:2004-06-24
  • 通讯作者: 庄峙厦(1956年出生),男,高级工程师,从事生物传感器和生物芯片研究.E-mail:zxzhuang@xmu.edu.cn E-mail:zxzhuang@xmu.edu.cn
  • 基金资助:

    国家“八六三”计划项目(批准号:2003AA635070)资助

Preparation of Molecular Imprinting Sol-gel Nanotubes Membrane and Its Application to Biochemical Separations

ZHANG Shu-Qiong1, YANG Huang-Hao2, ZHUANG Zhi-Xia1,2, WANG Xiao-Ru1,2   

  1. 1. The Key Laboratory of Analytical Sciences of MOE, Department of Chemistry, Xiamen University, Xiamen 361005, China;
    2. Material Transport & Transformation in Environmental & Life Processes Lab, The First Institute of Oceanography, SOA, Qingdao 266061, China
  • Received:2003-12-09 Online:2004-06-24 Published:2004-06-24

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摘要： 分子印迹技术(M IT)是20世纪末出现的一种高选择性分离技术,由于M IT模仿了生物界的锁钥作用原理,使制备的材料(M IT polymer,M IP)具有极高的选择性.同时,M IP又是人工合成的高分子,具有非常好的稳定性,并且制备简单,因此在固相萃取、不对称催化和传感器等相关领域得到了广泛的应用[1～5].目前,M IT存在的主要问题是所制备的M IP对目标分子的结合量小,可接触性差,达到结合平衡的时间长,且在制备过程中所使用的印迹分子难以完全洗脱.

关键词: 分子印迹, 纳米管, 溶胶-凝胶法, 生化分离

Abstract: Molecular imprinting has become a powerful method for the preparation of robust materials that have the ability to recognize a specific chemical species. The stability,ease of preparation and low cost of these materials have led to their assessment as substitutes for antibodies or enzymes in chemical sensors,catalysis and separations. The present techniques used to prepare molecular imprinting materials most often result in materials exhibiting a high affinity and selectivity but low capacity and poor site accessibility of the target molecules. In this study,we report a simple procedure for applying molecular imprinting functional groups to the inner surfaces of the AAO template-synthesized sol-gel nanotubes for biochemical separation of estrone. Using of nanotubes as the imprinted materials has the advantage of high affinity,selectivity,capacity and site accessibility for the target molecules. And it is important to emphasize that template route can be used to prepare imprinted nanotubes of nearly any materials.

Key words: Molecular imprinting, Nanotubes, Sol-gel method, Biochemical separation

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