高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (4): 762.

• 研究论文 • 上一篇    下一篇

N-苯甲氧羰基-L-色氨酸为模板的单分散分子印迹聚合物微粒的制备

郭天瑛, 张丽影, 郝广杰, 宋谋道, 张邦华   

  1. 南开大学高分子化学研究所, 吸附分离功能高分子材料国家重点实验室, 天津 300071
  • 收稿日期:2003-01-21 出版日期:2004-04-24 发布日期:2004-04-24
  • 通讯作者: 郭天瑛(1965年出生),男,博士,副教授,主要从事功能高分子材料的研究.E-mail:tyguo@nankai.edu.cn E-mail:tyguo@nankai.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:50003006)资助

Preparation of Uniform-sized Molecularly Imprinted PolymerMicrospheres Using N-Cbz-L-Trp as Template

GUO Tian-Ying, ZHANG Li-Ying, HAO Guang-Jie, SONG Mou-Dao, ZHANG Bang-Hua   

  1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
  • Received:2003-01-21 Online:2004-04-24 Published:2004-04-24

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被引次数

33

摘要： 采用两步溶胀与悬浮聚合联用方法,以2-乙烯基吡啶(2-VP)为功能单体,二乙二醇二丙烯酸酯(DEGDA)为交联剂,成功制备出以N-苯甲氧羰基-L-色氨酸(N-Cbz-L-Trp)为模板的单分散分子印迹聚合物,并用扫描电镜、氮气吸附、拉曼光谱、高效液相色谱、热失重分析等测试手段进行表征.结果表明,分子印迹聚合物的平均粒径为6.3μm,多分散系数为1.03.拉曼光谱显示聚合物反应完全,模板分子洗脱充分.高效液相色谱表征显示,分子印迹聚合物在很短的色谱柱中即可实现对印迹分子对映异构体的基线分离.

关键词: 分子印迹聚合物, 单分散, 氨基酸衍生物

Abstract: Uniform-sized molecularly imprinted polymer microspheres were prepared by using N-benzyloxycarbonyl-L-tryptophane(N-Cbz-L-Trp) as the template via a multi-step swelling and suspension polymerization method in which 2-vinylpyridine(2-VP) was used as the functional monomer and diethylene glycol diacrylate(DEGDA) was used as the cross-linker. The surfaces of nonporous micropheres were rough. The average diameter of polymer micropheres was 6.3 μm, and its distribution coeffiene was 1.03. It was found that the baseline chiral separation of the template enantiomer was achieved on a shorter column. Moreover, the removing of the template molecule and the thermal stability of MIP micropheres were also discussed.

Key words: Molecularly imprinted polymer, Uniform-sized dispersion, Amino acid derivatives

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