高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (12): 2195.

• 研究论文 •    下一篇

水溶性药物巯甲丙脯酸/Si-MCM-41载药新体系的制备与缓释作用研究

曲凤玉1,2, 朱广山1, 黄世英1, 李守贵1, 裘式纶1   

  1. 1. 吉林大学无机合成与制备化学国家重点实验室, 长春130023;
    2. 佳木斯大学化学与药学院, 佳木斯154007
  • 收稿日期:2004-06-23 出版日期:2004-12-24 发布日期:2004-12-24
  • 基金资助:

    国家自然科学基金(批准号:29873017,20101004);国家重大基础研究“九七三”计划(批准号:G2000077507)资助

Preparation and Sustained Release of a New Water-soluble Drug Carrier System Captopril/Si-MCM-41

QU Feng-Yu1,2, ZHU Guang-Shan1, HUANG Shi-Ying1, LI Shou-Gui1, QIU Shi-Lun1   

  1. 1. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, China;
    2. Chemistry and Pharmaceutical College, Jiamusi University, Jiamusi 154007, China
  • Received:2004-06-23 Online:2004-12-24 Published:2004-12-24

摘要: 采用浸渍法将水溶性的抗高血压药物巯甲丙脯酸组装到Si-MCM-41的孔道中,药物组装量达33.99%[m(药物)/m(载体)];用XRD,IR和固体紫外法对药物组装体进行了表征;通过测定组装体在体外模拟人工胃液中的释放速率,表明制得了巯甲丙脯酸/Si-MCM-41缓释释放体系.

关键词: 介孔分子筛, Si-MCM-41, 巯甲丙脯酸, 组装, 缓释作用

Abstract: Water-soluble anti-hypertension drug Captopril was incorporated in Si-MCM-41 channel by using impregnation wetness method, the mass fraction of drug[m(drug)/m(Si-MCM-41)] was 33.99%. Captopril/Si-MCM-41 assembly was characterized by XRD, IR, UV-visible technique. The sustained release profile was observed by soaking the assembly in vitro simulated stomach fluid. The results suggest that a Captopril/Si-MCM-41 sustained release system was obtained.

Key words: Mesoporous, Si-MCM-41, Captopril, Assembly, Sustained release

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