高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (5): 916.

• 论文 • 上一篇    下一篇

聚氨酯表面构建磺铵两性离子结构及其抗血小板粘附性的研究

袁江, 袁幼菱, 沈健, 林思聪   

  1. 南京大学表面和界面化学工程技术研究中心, 南京 210093
  • 收稿日期:2002-03-20 出版日期:2003-05-24 发布日期:2003-05-24
  • 通讯作者: 林思聪(1934年出生),男,教授,主要从事生物医用材料分子工程研究.E-mail:sicong_lin@ryahoo.com E-mail:sicong_lin@ryahoo.com
  • 基金资助:

    973国家重点基础研究发展规划项目(批准号:G1999064705)资助

Construction of Sulfoammonium Zwitterionic Structure onto Surface of Polyurethane by Hexamethylene Diisocyanate (HDI) Spacer for Improving Blood Compatibility

YUAN Jiang, YUAN You-Ling, SHEN Jian, LIN Si-Cong   

  1. Research Center of Surface and Interface Chemical and Engineering Technology, Nanjing University, Nanjing 210093, China
  • Received:2002-03-20 Online:2003-05-24 Published:2003-05-24

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被引次数

31

摘要： 通过己二异氰酸酯(HDI)在聚醚氨酯(PU)表面构建磺铵两性离子结构,以改善其不凝血性能,首先用HDI活化PU表面,生成PU-NCO衍生物;然后通过N,N-二甲基乙醇胺(DMEEA)中的-OH和PU表面的-NCO反应生成PU-N(CH3)2;最后用丙磺酸内酯(PS)进行开环.生成磺铵两性离子结构,用ATR-IR表征了各步反应,对构建前后材料的抗血小板粘附性能进行了比较,结果表明,磺铵两性离子结构具有优异的抗血小板粘附性.

关键词: 聚醚聚氨酯, 磺铵两性离子结构, 表面改性, 血小板粘附, 不凝血生物材料

Abstract: At the molecular level, it is believed that polymers containing zwitterionic structure should be more compatible with blood. The films of polyether-urethane were constructed with sulfoammonium zwitterionic structure by a three-step procedure. In the first step, the film surfaces were treated with hexam-ethylene diisocyanate(HDI) in toluene at 50 'Cin the presence of dibutyltin dilaurate(DBTDL) as a catalyst. The extent of the reaction was measured by ATR-IRspectra. Amaximum number of NCOgroups were obtained in about 90 min reaction. In the second step, the hydroxy groups of N, N-dimethylethylethanolamine (DMEEA) were allowed to react in toluene with surface bound isocyanate groups. In the third step, sulfoammonium zwitterionic structures were constructed onto the surface through the ring-opening reaction between tertiary amine constructed by the second step and 1,3-propane-sultone(PS). The surface was characterized by ATR-IR and XPS, and as anticipated, the sulfoammonium structure was constructed on the PU films. The platelet adhesion test revealed that films attached to sulfoammonium zwitterionic structure showed an excellent anti-platelet adhesion. These good results are due to the interfacial sulfoammonium zwitterionic structure.

Key words: Polyether-urethane, Sulfoammonium zwitterionic structure, Surface modification, Platelet ad- hesion, Nonthrombogenic biomaterials

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