高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (5): 1270.doi: 10.7503/cjcu20121016

• 高分子化学 • 上一篇    下一篇

结构可切换型聚合物刷的构建及表面性能

张琴, 高娜, 杨扬, 宫永宽, 王彦兵, 张世平, 史素青   

  1. 合成与天然功能分子化学教育部重点实验室, 西北大学化学与材料科学学院, 西安 710069
  • 收稿日期:2012-11-09 出版日期:2013-05-10 发布日期:2013-05-10
  • 通讯作者: 史素青, 女, 博士, 副教授, 主要从事仿生物污染表/界面的研究. E-mail: shisq@nwu.edu.cn E-mail:shisq@nwu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 21004047)、 陕西省教育厅专项科研计划(批准号: 09JK767)、 陕西省自然科学基础研究计划(批准号: 2010JQ2004)和中国博士后科学基金(批准号: 20100471629, 201104673)资助.

Fabrication and Surface Properties of Structure-switchable Polymer Brush by Photografting Method

ZHANG Qin, GAO Na, YANG Yang, GONG Yong-Kuan, WANG Yan-Bing, ZHANG Shi-Ping, SHI Su-Qing   

  1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, China
  • Received:2012-11-09 Online:2013-05-10 Published:2013-05-10

PDF (PC)

被引次数

6

摘要：

合成了结构可切换型甲基丙烯酸酯季铵盐(CBMA-1C2). 在聚丙烯(PP)片基表面光接枝构建CBMA-1C2聚合物刷, 其在碱性水溶液中可水解形成两性离子聚合物刷PCBMA. 用蛋白质吸附及血小板黏附实验评价改性表面亲/疏水性及表面电荷对生物分子与材料表面之间相互作用的影响. 结果发现, 与未改性PP片基相比, 聚合物PCBMA-1C2改性表面水解前后均具有优异的亲水性能, 由于聚合物PCBMA-1C2水解前后表面电荷不同, 对生物分子与改性PP表面的相互作用表现出明显差异. 亲水性好、 两性离子结构的聚合物PCBMA表面表现出对蛋白吸附和血小板黏附的良好抑制作用.

关键词: 光接枝, 聚合物刷, 表面改性, 蛋白质吸附, 血小板黏附

Abstract:

A structure-switchable monomer N,N-dimethyl-N-(ethoxycarbonylmethyl)-N[2'-(methacryloyloxy)ethyl]-ammoniumbromide(CBMA-1C2) was synthesized. The polymer brush of PCBMA-1C2 was fabricated on the polypropylene(PP) surface by photografting polymerization method, which could be hydrolyzed in alkaline aqueous solution to produce the polymer brush PCBMA surface(PP-PCBMA) with zwitterionic structure. The attenuated total reflectance infrared(ATR-IR) spectroscopy and X-ray photoelectron spectroscopy(XPS) were used to characterize the modified PP surface. The hydrophilia/hydrophobicity of PP before and after photografting and hydrolysis were measured by static contact angle measurements. The uniformity of surface elemental composition was monitored by dynamic contact angle measurements. The effect of hydrophilicity/hydrophobicity and charge types of the surface on the interactions between biological molecules and material surface were assessed by protein adsorption and platelet adhesion experiment. The results show that the PP-PCBMA-1C2 and PP-PCBMA have good hydrophilic properties. However, the difference in surface charge types made their protein adsorption and platelet adhesion behavior greatly different. The results suggested that the PP surface with good hydrophilicity and zwitterionic structure exhibited strong resistance of protein adsorption and platelet adhesion.

Key words: Photografting, Polymer brush, Surface modification, Protein adsorption, Platelet adhesion

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