高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (1): 205.doi: 10.7503/cjcu20120430

• 高分子化学 • 上一篇    下一篇

聚苯乙烯共价键合磷铵两性离子的结构修饰及血液相容性

金灿1, 江玉亮1, 钱涛1, 韩巧荣1, 王炳祥1, 沈健1,2   

  1. 1. 江苏省生物功能材料重点实验室, 江苏省生物医药功能材料工程研究中心, 南京师范大学化学与材料科学学院, 南京 210097;
    2. 南京大学江苏省表面与界面工程技术研究中心, 南京 210093
  • 收稿日期:2012-04-29 发布日期:2012-12-31
  • 通讯作者: 王炳祥,男,博士,教授,主要从事有机化学研究.E-mail:wangbingxiang@njnu.edu.cn;沈健,男,博士,教授,主要从事生物材料的合成与性质研究.E-mail:jshen@njnu.edu.cn E-mail:wangbingxiang@njnu.edu.cn;jshen@njnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20874047)和江苏省高校优势学科建设工程资助项目资助.

Surface Modification of Polystyrene via Covalently-attaching Phosphorylcholine Zwitterion and Its Blood Compatibility

JIN Can1, JIANG Yu-Liang1, QIAN Tao1, HAN Qiao-Rong1, WANG Bing-Xiang1, SHEN Jian1,2   

  1. 1. Jiangsu Province Key Laboratory of Biofunctional Materials, Jiangsu Province Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China;
    2. Jiangsu Province Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
  • Received:2012-04-29 Published:2012-12-31

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被引次数

12

摘要：

利用形成碳-氧键将磷铵两性离子(1)共价键合到聚苯乙烯(PS)材料表面, 改善其抗凝血性能. 首先对PS进行氯甲基化反应, 生成苄氯结构, 然后通过自合成化合物1中的-OH与氯甲基化聚苯乙烯的-CH2Cl反应形成醚键, 将两性离子接枝在PS上. 表征了产物结构, 并通过水接触角和血小板黏附实验对结构修饰前后材料的亲水性和抗凝血性能进行了比较. 结果表明, 磷铵两性离子结构修饰的聚苯乙烯材料可以有效地提高其血液相容性.

关键词: 聚苯乙烯, 磷铵两性离子, 表面改性, 血小板黏附, 抗凝血生物材料

Abstract:

To be more compatible with blood, polystyrene(PS) was covalently-attached with phosphorylcholine(1) via ether bond. After activated by chloromethylation reaction, the PS was constructed with compound 1 by the reaction between benzyl chloride and hydroxyl group. The existence of phosphorylcholine structure onto the surface of PS was revealed by attenuated total reflection Fourier transform infrared spectroscopy(ATR-FTIR) and 1H NMR. The contact angle measurement of grafted PS membrane indicated that the grafted films possessed relatively hydrophilic surface. The blood compatibilities of grafted PS were evaluated by platelet-rich plasma adhesion experiment. The novel segmented PS containing phosphorylcholine structure improved blood compatibility.

Key words: Polystyrene, Phosphorylcholine zwitterion, Surface modification, Platelet adhesion, Antithrombogenic biomaterial

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