高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (1): 79.

• 研究简报 • 上一篇    下一篇

利用三溴化铟催化的Biginelli反应原位合成3,4-二氢嘧啶-2-酮

傅南雁, 袁耀锋, 庞美丽, 王积涛   

  1. 南开大学化学系, 天津 300071
  • 收稿日期:2001-11-16 出版日期:2003-01-24 发布日期:2003-01-24
  • 通讯作者: 王积涛(1918年出生),男,博士,教授,博士生导师,主要从事金属有机化学研究.E-mail:wangjt@nanka.iedu.cn E-mail:wangjt@nanka.iedu.cn
  • 基金资助:

    国家自然科学基金(批准号:29872018,29972026);南开大学元素有机国家重点实验室和教育部博士学科点基金(批准号:1999005520)资助

A Novel One-pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones Catalyzed by Indium Tribromide

FU Nan-Yan, YUAN Yao-Feng, PANG Mei-Li, WANG Ji-Tao   

  1. Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2001-11-16 Online:2003-01-24 Published:2003-01-24

PDF (PC)

被引次数

57

关键词: Biginelli反应, 三溴化铟, 3, 4-二氢嘧啶-2-酮, 氧桥

Abstract: A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product from β-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.

Key words: Biginelli reaction, Indium(Ⅲ) tribromide, 3,4-Dihydropyrimidinone, Oxygen bridge

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