高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (7): 1324.

• 研究简报 • 上一篇    下一篇

3,11(13)-二烯-12-桉烷酸的立体选择性全合成

周罡, 陈永刚, 关玉昆, 郑国君, 李裕林   

  1. 兰州大学应用有机化学国家重点实验室, 兰州 73000
  • 收稿日期:2001-02-05 出版日期:2002-07-24 发布日期:2002-07-24
  • 通讯作者: 李裕林(1935年出生),男,教授,博士生导师,从事有机合成化学研究.E-mail:liyl@lzu.edu.cn E-mail:liyl@lzu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29732060)

Enantioselective Total Synthesis of 12-Carboxyeudesma-3,11(13)-diene

ZHOU Gang, CHEN Yong-Gang, GUAN Yu-Kun, ZHENG Guo-Jun, LI Yu-Lin    

  1. National Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2001-02-05 Online:2002-07-24 Published:2002-07-24

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被引次数

8

关键词: 3, 11(13)-二烯-12-桉烷酸, 不对称全合成, (-)-二氢香芹酮

Abstract: The enantioselective total synthesis of 12-carboxyeudesma-3, 11(13)-diene(1) was achieved starting from(-)-dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C-12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.

Key words: 12-Carboxyeudesma-3,11(13)-diene, Enantioselective total synthesis, (-)-Dihydrocarvone

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