高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (7): 1073.

• 论文 • 上一篇    下一篇

血清白蛋白对紫杉醇的化学修饰

邱晓航, 巢晖, 周永洽   

  1. 南开大学化学系, 天津 300071
  • 收稿日期:1998-12-23 出版日期:1999-07-24 发布日期:1999-07-24
  • 通讯作者: 邱晓航,女,31岁,博士研究生.
  • 作者简介:邱晓航,女,31岁,博士研究生.

The Modification of Taxol with Improving Water Solubility

QIU Xiao-Hang, CHAO Hui, ZHOU Yong-Qia   

  1. Department of Chemistry, Nankai University, Tianjin, 300071
  • Received:1998-12-23 Online:1999-07-24 Published:1999-07-24

PDF (PC)

被引次数

27

摘要： 采用两种方法由牛血清白蛋白和人血清白蛋白修饰紫杉醇,提高了水溶性.红外和紫外数据证实了修饰结果.

关键词: 紫杉醇, 牛血清白蛋白, 人血清白蛋白, 修饰

Abstract: TaxoLIs a product isolated from the pacitic yew tree and is a potent microtubule-stablizing agent which has been approved for treatment of otherwise intractable ovarian can-cer and beast cancer. Despite taxol’s therapeutic promise, its aqueous insolubility hampers its clinical application. Here we report two ways to modify taxol with BSA or HSA which can improve taxol's solubility. The IRdata and UVabsorption are given to confirm the modification.

Key words: Taxol, BSA, HSA, Modification

中图分类号: 

TrendMD: