高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (6): 906.

• 研究简报 • 上一篇    下一篇

1,5-苯并硫氮杂氯代β-内酰胺衍生物的合成、光谱及立体化学

李媛1, 杜彩云2, 杨秋青3, 金声4, 邢其毅4   

  1. 1. 河北师范大学, 石家庄 050016;
    2. 河北师范大学, 邯郸高等农业专科学校基础部, 邯郸 057150;
    3. 河北师范大学, 实验中心, 石家庄 050016;
    4. 北京大学化学与分子工程学院, 北京 100871
  • 收稿日期:1998-06-29 出版日期:1999-06-24 发布日期:1999-06-24
  • 通讯作者: 李媛,女,41岁,副教授.
  • 作者简介:李媛,女,41岁,副教授.
  • 基金资助:

    河北省教育委员会资助

Synthesis, Spectra and Stereochemistry of β-Lactam Derivatives of 1,5-Benzothiazepines

LI Yuan1, DU Cai-Yun2, YANG Qiu-Qing3, JIN Sheng4, XING Qi-yi4   

  1. 1. Department of Chemistrya, Hebei Normal Universitya, Shijiazhuang, 050016;
    2. Experiment Centerc, Hebei Normal Universitya, Shijiazhuang, 050016;
    3. Department of Chemistrya, Experiment Center, Hebei Normal Universitya, Shijiazhuang, 050016;
    4. Department of Basic Courseb, Handan Agricultural College, Handan, 057150
  • Received:1998-06-29 Online:1999-06-24 Published:1999-06-24

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摘要： 苯并硫氮杂是一类具有重要生理活性的七元杂环化合物,近年来,通过亚胺双键(CN)的环加成反应向此类化合物分子中引入新的环系引起了人们的关注[1～4].这项工作对于合成新的杂类化合物从而筛选出具有特殊生理活性的物质有着重要意义.

关键词: 1, 5-苯并硫氮杂, &beta, -内酰胺, 立体结构

Abstract: Five title compounds were synthesized, their spectra and steric structures have been studied. The result reveals that the conformation of these compounds is chair-like, the chloro and phenyl substituents on C-2 and C-3 are cis to the fourmembered ring, the reaction of 1,5-benzothiazepine with chloroacelyl chloride is stereospecific reaction.

Key words: 1,5-Benzothiazepine, β-Lactam, Steric structure

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