高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (12): 1850.

• 研究简报 • 上一篇    下一篇

手性三菲咯啉合镍与DNA的立体选择性研究

宋玉民, 康敬万, 王志华, 卢小泉, 高锦章   

  1. 西北师范大学化学系, 兰州 730070
  • 收稿日期:1999-02-11 出版日期:1999-12-24 发布日期:1999-12-24
  • 通讯作者: 康敬万
  • 作者简介:宋玉民,女,49岁,硕士,副教授.
  • 基金资助:

    甘肃省中青年基金(批准号:ZQ-95-011)资助课题

Studies on Stereoselectivity in Tris(phenanthroline) Nickel(Ⅱ) Binding to DNA

SONG Yu-Min, KANG Jing-Wan, WANG Zhi-Hua, LU Xiao-Quan, GAO Jin-Zhang   

  1. Department of Chemistry, Northwest Normal University, Lanzhou 730070, China
  • Received:1999-02-11 Online:1999-12-24 Published:1999-12-24

关键词: 镍, 菲咯啉, DNA

Abstract: Binding of Δ-, Λ-[Ni(phen)3]2+to calf thymus DNAwas studied by circular dichroism and electrochemical methods. The selectivity of Δ isomer in binding to a right-handed duplex of DNAwas found. Binding constants and binding site sizes for Δ-and Λ-[Ni(phen)3]2+with DNAwere determined from voltammetric data.

Key words: Nickel, Phenanthroline, DNA

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