高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (1): 19.

• 研究快报 • 上一篇    下一篇

5-(2-羧基苯基)-10,15,20-三苯基卟啉对氨基酸酯的分子识别模型研究

彭小彬, 黄锦汪, 计亮年   

  1. 中山大学化学系, 广州 510275
  • 收稿日期:1998-07-29 出版日期:1999-01-24 发布日期:1999-01-24
  • 基金资助:

    国家自然科学基金;广州省自然科学基金;马灿安教育基金

The Study of Molecular Recognition of 5(2-Carboxyphenyl)10,15,20 triphenylporphyrin to Amino Acid Esters

PENG Xiao-Bin, HUANG Jin-Wang, JI Liang-Nian   

  1. Department of Chemistry, Zhongshan University, Guangzhou, 510275
  • Received:1998-07-29 Online:1999-01-24 Published:1999-01-24

摘要: 对氨基酸及其衍生物的分子识别一直是仿生化学领域中的重要课题.以金属卟啉配合物作为主体分子对氨基酸酯的分子识别是最近几年来的热点之一[15].氨基酸是蛋白质的主要组成部分,在蛋白质合成过程中,对氨基酸及其衍生物的识别是关健的一步.

关键词: 卟啉, 氨基酸酯, 分子识别新模型

Abstract: Using UV-Vis spectroscopic and 1HNMR methods, we have invest igated The molecu lar recognition of am ino acid esters by 5(2 carbox ypheny l)10, 15, 20 tripheny lporphyrin.The binding const ants between o-TPPCO2H and Lphenylalanine ethylester, and Lthreonine ethyl ester were obt ained.The possible recognition mode of The free porphyrin to amino acid esters has been suggested.The hydrogen bond between one of The two hydrogens of pyrroL in o-TPPCO2H and The oxygen of The carboxyl group of amino acid ester acts as one point of interaction.Another pointof interaction is The base acid interaction between amino group of amino acid ester and car boxyl group of porphyrin.

Key words: Porphyrin, Amino acid esters, New mode of molecular recognition

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