高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (9): 1479.

• 论文 • 上一篇    下一篇

含酯基包覆聚合物液相色谱柱填料

左育民1, 张鲲1, 吕文硕1, 许晓文1, 庞志龙2, 齐静娴2   

  1. 1. 南开大学化学系, 天津 300071;
    2. 天津化学试剂二厂, 天津 30021O
  • 收稿日期:1996-07-24 出版日期:1997-09-24 发布日期:1997-09-24
  • 通讯作者: 左育民, 男, 59岁, 教授,
  • 作者简介:左育民, 男, 59岁, 教授,
  • 基金资助:

    国家自然科学基金;南开大学吸附分离功能高分子材料国家重点实验室资助

Ester-Containing Polymer Encapsulated PackingMaterial for Liquid Chromatography

ZUO Yu-Min1, ZHANG Kun1, LU Wen-Shuo1, XU Xiao-Wen1, PANG Zhi-Long2, QI Jing-Xian2   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071;
    2. Tianjin No. 2 Chemical Reagent Factory, Tianjin 300210
  • Received:1996-07-24 Online:1997-09-24 Published:1997-09-24

摘要: 以丙烯酸甲酯或辛酯和二乙烯苯为原料, 在溶液中用游离基聚合法制备了一系列含酯基包覆聚合物反相液相色谱柱填料.用傅立叶红外光谱、电子显微镜和元素分析鉴定了聚合物层, 并评价了诸如硅羟基、柱压降、柱效和峰对称性等特性.该类填料适合于含氨基和羟基化合物的分离, 作为应用实例, 对洛伐他汀(Lovastatin)的分析展示其优良的色谱性能。

关键词: 液相色谱, 包覆聚合物, 柱填料, 丙烯酸酯-二乙烯苯共聚物

Abstract: Aseries of ester-containing polymer encapsulated packing material for reversedphase high performance liquid chromatography was prepared by radical polymerization ofmethyl or octyl acrylate and divinylbenzene with vinyl-bonded silica in solution. The polymerlayer was characterized by FTIR, SEMand elemental analysis. Some characteristics such asresidual silanols, column pressure, column efficiency and peak asymmetry were evaluated.The polymer encapsulated packing materials are inorganic packings with organic coatings,thus combining the favorable mechanical properties of silica nuclei with the favorablechemical stability of polymer coatings. The plots of lgk' of solute against methanol content of amobile phase using the packing material. In the case of aniline, benzene, and o-nitrophenol,the plots have a linearity similar to those of reversed phase packings. These packings weresuitable for separation of amino-and hydroxyl groups containing compounds because of thestability and the absence of acidic silanol groups. At the same time, they will play animportant role in rapid separations of complex mixtures because the mass transfer to the stationaryphase is fast. Its superior performance for the analysis of Lovastatin is demonstrated asapplication example.

Key words: Liquid chromatography, Polymer encapsulated packings, Column packing, Acrylate-divinylbenzene copolymer

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