高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (1): 149.

• 论文 • 上一篇    下一篇

主链含酪氨酸的聚磷酸酯抗肿瘤药物的研究

范昌烈, 胡斌, 卓仁禧, 杜阳   

  1. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1996-01-23 出版日期:1997-01-24 发布日期:1997-01-24
  • 通讯作者: 卓仁禧
  • 作者简介:范昌烈, 男, 56岁, 副教授.
  • 基金资助:

    国家自然科学基金

Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs

FAN Chang-Lie, HU Bin, ZHUO Ren-Xi, DU Yang   

  1. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1996-01-23 Online:1997-01-24 Published:1997-01-24

摘要: 通过含酪氨酸的聚磷酸酯与药物分子进行大分子反应,制备了含5-氟尿嘧啶或氨甲蝶呤的聚磷酸酯.所得聚磷酸酯均具有两亲性,部分聚磷酸酯在水中能形成胶束.研究了这些聚合物的体外降解和释药性能,体外抗肿瘤实验表明,有些聚磷酸酯药物具有较强的抗肿瘤活性.

关键词: 聚磷酸酯, 酪氨酸, 两亲性, 5-氟尿嘧啶, 氨甲蝶呤

Abstract: New polyphosphate antitumor durgs containing 5-Fu or MTXwere synthesized by macromolecular reaction of polyphosphates with the corresponding drug molecules.All these polyphosphates obtained are amphiphilic, some of them have micelle-forming properties.The hydrolysis and in vitro drug release properties of these polyphosphates were studied.The in vitro antitumor activity data showed that some of these polyphosphates exhibit good antitumor activity.

Key words: Polyphosphate, Tyrosine, Amphiphilicity, 5-Fluorouracil, Methotrexate

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