高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (7): 1078.

• 论文 • 上一篇    下一篇

氟代碳核苷类化合物的合成研究──N-烷基-5-甲酰胺基-1,2,4-氧杂二唑基-3-(4＇-脱氧-4＇-氟-β-L-吡喃型阿拉伯糖)的合成

程华, 马灵台, 张礼和   

  1. 北京医科大学药学院, 北京 100083
  • 收稿日期:1995-08-25 出版日期:1996-07-24 发布日期:1996-07-24
  • 通讯作者: 张礼和
  • 作者简介:程华,男,32岁,硕士研究生.
  • 基金资助:

    国家自然科学基金

Studies on the Synthesis of Fluorinated C-Nucleosides──Synthesis of N-Alkyl 3-(4'-deoxy-4'-fluoro-β-L-arabinopyranosyl)-1,2,4-oxadiazole-5-carboxamides

CHENG Hua, MA Ling-Tai, ZHANG Li-He   

  1. School of Pharmaceutical Sciences, Beijing Medical University 100083
  • Received:1995-08-25 Online:1996-07-24 Published:1996-07-24

PDF (PC)

摘要： 报道了N-烷基5-甲酰胺基-1,2,4-氧杂二唑基-3-β-D-吡喃木糖用二乙胺基三氟化硫选择性氟化,得到相应的N-烷基-5-甲酰胺基-1,2,4-氧杂二唑基-3-(4'-脱氧-4'-氟-β-L-吡喃型阿拉伯糖);并用光谱分析确证了它们的构型及在溶液中的构象。

关键词: 1, 2, 4-氧杂二唑, 选择性氟化, 碳核苷

Abstract: N-Alkyl-3-(4'-deoxy-4'-fluoro-β-L-arabinopyranosyl)-1,2,4-oxadiazole-5-carboxamids were synthesized from the corresponding N-alkl 3-β-D-xylopyranosyl-1,2,4-oxadiazole-5-carboxamides which were selectively fluorinated at 4'-position of sugar moiety with diethylaminosulfur trifluoride(DAST).The configuration and conformation of these new Cnucleoside derivatives were identified by 1H NMR,13C NMR,19F NMR,1HH-1HH COSY and MS.

Key words: 1,2,4-Oxadiazole, Selective fluorination, C-Nucleoside

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