高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (3): 339.

• 论文 • 上一篇    下一篇

头孢噻肟钠的降解及其产物伏安行为的研究

李启隆, 陈寿爱, 尚军   

  1. 北京师范大学化学系, 北京, 100875
  • 收稿日期:1993-03-06 修回日期:1993-05-21 出版日期:1994-03-24 发布日期:1994-03-24
  • 通讯作者: 李启隆,男,55岁,博士,教授.
  • 作者简介:李启隆,男,55岁,博士,教授.
  • 基金资助:

    国家自然科学基金

Studies on the Degradation of Cefotaxime and Voltammetric Behaviour of Degradation Product

LI Qi-Long, CHEN Shou-Ai, SHANG Jun   

  1. Deparment of Chemistry, Beijing Normal University, Beijing, 100875
  • Received:1993-03-06 Revised:1993-05-21 Online:1994-03-24 Published:1994-03-24

PDF (PC)

被引次数

31

摘要： 头孢噻肟钠在NaOH溶液中降解后,于0.1mol/LNaOH中得一灵敏的吸附伏安还原峰,Ep=-0.78V(vs,Ag/AgCl),ip与头孢噻肟钠浓度在1.0×10-9～1.0×10-8、1.0×10-8～1.0×10-7、1.0×10-7～1.0×10-6mol/L范围内呈线性关系,检出限为5.0×10-10mol/L,用多种电化学手段研究其降解产物的伏安行为,测定了电极反应的有关参数,探讨了降解反应和电极反应机理。实验表明,体系属准可逆吸附波。

关键词: 头孢噻肟钠, 降解, 吸附溶出伏安法

Abstract: The degradation of cefotaxime was carried out in NaOHsolution at 100℃ for 20min.Asensitive reduction peak of degradation product was obtained by adsorptive stripping voltammetry in 0.1 mol/L NaOH, at accumulation time of 60 s.Ep=-0.78 V (vs.Ag/AgCl).ip is directly proportional to the concentration of cefotaxime over the range from 1.0×10-9 to 1.0×10-6 mol/L, with a detection limit of 5.0×10-10 mol/L.The voltammetric behaviour of degradation product has been studied.The parameters of electrode reaction have been determined.The mechanisms about the degradation and electrode reactions were discussed.

Key words: Cefotaxime, Degradation, Adsorptive stripping voltammetry

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