高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (7): 954.

• 研究简报 • 上一篇    下一篇

荧光素衍生物抗癌活性的模式识别

李丙瑞, 何凤英, 王流芳   

  1. 兰州大学化学系, 兰州 730000
  • 收稿日期:1992-07-09 修回日期:1992-12-22 出版日期:1993-07-24 发布日期:1993-07-24
  • 通讯作者: 王流芳.
  • 作者简介:第一作者:男, 43岁, 讲师.
  • 基金资助:

    国家自然科学基金

Pattern Recognition for the Antitumour Activity of Some Fluorescein Derivatives

LI Bing-Rui, HE Feng-Ying, WANG Liu-Fang   

  1. Department of Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1992-07-09 Revised:1992-12-22 Online:1993-07-24 Published:1993-07-24

关键词: 模式识别, 构效关系, 荧光素衍生物, 抗癌活性

Abstract: In this paper, some antitumour fluorescein derivatives were classified according to their activity using Non-Linear Mapping (NLM) pattern recognition techniques.Three sets of structural parameters, {ΣMR, F2, (Σ)2}, {ΣMR, F2, π3} and {ΣMR, ΣF, (Σπ)2} were screened out.The results showed that the main structural factors influencing the antitumour activity of these substances are their molar refraction, hydrophobicity and field inductive effect, especially field inductive effect of 2-substituent, whereas conjugative effect is not.The forecast model about antitumour activity of the derivatives were established and further syntheses were suggested by this research.

Key words: Pattern recognition, Structure-Activity relationship, Fluorescein derivatives, Antitumour activity

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