高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (5): 532-533.

• 研究简报 • 上一篇    下一篇

3,4-二氢-4-氧嘧啶并[4,5-b]喹啉类化合物的合成

陈伟, 姜贵吉   

  1. 延边大学化学系
  • 收稿日期:1988-10-29 出版日期:1990-05-24 发布日期:1990-05-24
  • 通讯作者: 陈伟(现在南京制药厂工作)

Syntheses of 3,4-Dihydro-4-Oxopyrimido[4,5-b]Quinolines

Chen Wei, Jiang Guiji   

  1. Department of Chemistry, Yanbian University, Yanji
  • Received:1988-10-29 Online:1990-05-24 Published:1990-05-24

摘要: Althuis等曾研究了一系列新的3,4-二氢-4-氧嘧啶并[4,5-b]喹啉-2-羧酸抗敏剂的结构与活性的关系[1],得到比DSCG高400倍的药理活性.但对3-位N上取代基结构变化对药理活性的影响尚未见报道。

关键词: 喹啉, 嘧啶, 酰胺

Abstract: Syntheses of N-Substituted 3, 4-dihydro-4-oxopyrimido[4, 5-b]quinolines which were achieved by reaction of N-Substituted 2-aminoquinoline-3-carboxyamides with formamide are described in detail. The structures of 20 new compounds have been confirmed by element analysis, IR and 1H NMR.

Key words: Qulnoline, Pyrimidine, Amide