高等学校化学学报

高等学校化学学报 ›› 1988, Vol. 9 ›› Issue (12): 1207.

• 论文 •    下一篇

1-羟乙基二磷酸二钠(EHDP)对胆红素钙结晶形成的抑制作用

王夔, 许善锦, 胡加平, 程天蓉, 金凡   

  1. 北京医科大学药学院
  • 收稿日期:1987-05-25 出版日期:1988-12-24 发布日期:1988-12-24
  • 通讯作者: 许善锦

Inhibition of Crystal Formation and Aggregation of Calcium Bilirubinate with Disodium 1-Hydroxyethanediphosphonate(EHDP)

Wang Kui, Xu Shanjin, Hu Jiaping, Cheng Tianrong, Jin Fan   

  1. School of Pharmacy, Beijing Medical University, Beijing
  • Received:1987-05-25 Online:1988-12-24 Published:1988-12-24

PDF (PC)

被引次数

1

摘要： 研究了1-羟乙基二磷酸二钠(EHDP)在有,无胆酸钠(CA)存在下,对胆红素(BL)与钙离子反应生成胆红素钙结晶过程的影响。实验结果表明,EHDP对胆红素钙结晶的形成有抑制作用,而胆酸钠的存在加强了这一作用。

关键词: 1-羟乙基二磷酸二钠, 胆红素钙, 抑制

Abstract: Disodium 1-hydroxyethanediphosphoriate was studied as an inhibitor of the formation and aggregation of calcium bilirubinate, the main component of pigment gallstone.The kinetics of calcium bilirubinate formation was studied at pH 7.9, 37+1℃, under nitrogen atmosphere, in the darkness. EHDPwas added in different levels, with or without choric acid. It is obvious that EHDPis able to inhibit the precipitation of calcium bilirubinate and the coexisted choric acid enhances this effect.The effect of EHDPon the particle size was also studied with Coulter counter. The results show that EHDPinhibit the aggregation effectively and a strong synergic effect was observed between EHDP and choric acid.

Key words: Disodium 1-hydroxyethanediphosphonate, Calcium bilirubinate, Inhibition

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