高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

纤维基有机电化学晶体管葡萄糖传感器的制备及性能研究

李劲松,杨思蕊,孙世民,李中波,张利君   

  1. 安徽农业大学
  • 收稿日期:2024-09-16 修回日期:2024-10-13 出版日期:2024-11-05 发布日期:2024-11-05
  • 通讯作者: 张利君 E-mail:Ljunzhang@ahau.edu.cn
  • 基金资助:
    国家自然科学基金(批准号：52403218)、安徽高校自然科学研究项目（批准号：KJ2021A0131）和安徽农业大学大学生创新训练项目（批准号：X202410364365）资助

Preparation and Performance Study of Fiber-Based Organic Electrochemical Transistor Glucose Sensor

LI Jingsong, YANG Sirui, SUN Shiming, LI Zhongbo, ZHANG Lijun   

  1. Anhui Agricultural University
  • Received:2024-09-16 Revised:2024-10-13 Online:2024-11-05 Published:2024-11-05
  • Contact: lijun ZHANG E-mail:Ljunzhang@ahau.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No. 52403218), the Key Project of Natural Science of Anhui Provincial Department of Education, China(No. KJ2021A0131), and the College Student Innovation Training Program of Anhui Agricultural University, China(No. X202410364365)

PDF (PC)

摘要： 纤维基有机电化学晶体管具有柔性可穿戴、工作电压低、灵敏度高、生物相容性好等优点，在可穿戴电子器件、生物传感领域应用前景广阔。本论文以棉纤维为电极原料，利用石墨烯(Gr)以及聚( 3,4-乙撑二氧噻吩)-聚对苯乙烯磺酸钠(PEDOT:PSS)对纤维表面进行改性，在纤维表面形成一层PEDOT:PSS/Gr膜，所得PEDOT:PSS/Gr/fiber的电阻低至60 Ω/cm。用该导电纤维组装成有机电化学晶体管器件，并在器件的栅极修饰葡萄糖氧化酶，获得的有机电化学晶体管传感器具有稳定的输出性能和高灵敏度，在浓度1 pM-500 nM的范围内对葡萄糖检测具有良好的线性响应，且检测限低至1 pM。此外，该传感器对葡萄糖检测具有明显特异性，能够抵抗体液中常见干扰物尿酸、抗坏血酸和常见金属离子（K+、Na+、Mg2+）的干扰。将其用于唾液样品的检测，其回收率为104％- 117％，该研究可为糖尿病的血糖无创检测提供一定的参考和技术支持。

关键词: 纤维基有机电化学晶体管, 传感器, 葡萄糖, 无创检测

Abstract: Fiber-based organic electrochemical transistors have broad application prospects in the fields of wearable electronic devices and biosensor due to the advantages of being flexible and wearable, low working voltage, high sensitivity, and good biocompatibility. In this study, cotton fiber was used as the raw material for electrodes, and graphene (Gr) and poly(3,4-ethylenedioxythiophene)-sodium polystyrene sulfonate (PEDOT:PSS) were used to modify the fiber surface to form a layer of PEDOT:PSS/Gr film on the fiber surface. The resistance of the PEDOT:PSS/Gr/fiber was as low as 60 Ω/cm. An organic electrochemical transistor device with stable output performance and high sensitivity was constructed by PEDOT:PSS/Gr/fiber, and shown good linear response to glucose detection in the range of 1 pM-500 nM, with a detection limitation of 1 pM. In addition, it is demonstrated that the sensor can resist interference from uric acid, ascorbic acid, and common metal ions (K+, Na+, Mg2+), which are common interferences in body fluids. The recovery rate was 104% -117% when used to detect saliva samples. This study can provide some technical support for non-invasive detection of blood glucose in diabetes.

Key words: Fiber-based organic electrochemical transistors, Sensor, Glucose, Non-invasive testing

中图分类号: 

TrendMD: