高等学校化学学报

高等学校化学学报

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开环制备聚二硫化物及其在药物递送方面的应用

孙玉洁,牛振田,佟昊轩,胡悦,俞丙然,徐福建   

  1. 北京化工大学材料科学与工程学院，北京 100029
  • 收稿日期:2024-03-11 修回日期:2024-04-22 网络首发:2024-04-23 发布日期:2024-04-23
  • 通讯作者: 俞丙然 E-mail:yubr@mail.buct.edu.cn
  • 基金资助:
    国家重点研发计划（批准号：2021YFB3800900）和国家自然科学基金（批准号：22122501，52073013和52221006）资助.

Ring-opening Preparation of Poly(disulfide)s for Drug Delivery

SUN Yujie, NIU Zhentian, TONG Haoxuan, HU Yue, YU Bingran, XU Fujian   

  1. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2024-03-11 Revised:2024-04-22 Online First:2024-04-23 Published:2024-04-23
  • Contact: Bingran Yu E-mail:yubr@mail.buct.edu.cn
  • Supported by:
    Supported by the National Key R&D Program of China(No.2021YFB3800900) and the National Natural Science Foundation of China(Nos.52073013, 22122501 and 52221006).

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摘要： 二硫键的动态交换与重组，使其易于进行开环聚合（ROP）反应得到聚二硫化物。聚二硫化物因其还原环境敏感性而被广泛应用于药物递送领域。本文综述了二硫化物的ROP策略，主要分为开环自聚和巯基引发的双硫交换聚合。随后，讨论了聚二硫化物在药物递送方面的最新研究进展，主要包括核酸递送、蛋白质递送和小分子药物递送。

关键词: 双硫交换, 二硫键, 开环聚合, 药物递送

Abstract: The dynamic exchange and recombination of disulfide bonds make it easy to polymerization to obtain poly(disulfide)s, among which ring-opening polymerization (ROP) is a common preparation method. The environmental sensitivity of poly(disulfide)s makes it widely used in the field of drug delivery. In this paper, the ROP strategies of disulfide are reviewed, which are mainly divided into ring-opening self-polymerization and thiol-induced disulfide exchange polymerization. Then, the latest research progress of poly(disulfide)s in drug delivery is also discussed, including nucleic acid delivery, protein delivery and small molecule drug delivery.

Key words: Disulfide exchange, Disulfide bond, Ring-opening polymerization, Drug delivery

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