高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (11): 2356-2382.doi: 10.7503/cjcu20200319

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

有机小分子纳米粒子的光学诊疗应用

邵伟,LEE Jiyoung,李方园,凌代舜   

  1. 浙江大学药学院, 药物制剂研究所, 杭州 310058
  • 收稿日期:2020-06-02 出版日期:2020-11-10 发布日期:2020-11-06
  • 基金资助:
    国家重点研发计划“纳米科技”专项(2016YFA0203600)

Organic Small Molecule Nanoparticles for Phototheranostics

SHAO Wei, LEE Jiyoung, LI Fangyuan, LING Daishun()   

  1. Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China
  • Received:2020-06-02 Online:2020-11-10 Published:2020-11-06
  • Contact: LING Daishun E-mail:lingds@zju.edu.cn
  • Supported by:
    This paper is Foundation:supported by the National Key Research and Development Project-Nanotechnology Fun-ding, China(No.2016YFA0203600).

摘要:

癌症严重威胁着人类健康, 因此, 急需开发高效的诊断和治疗方法. 基于光敏剂和近红外激光的光学诊疗将诊断和治疗集于一体, 与传统的手术治疗和化学治疗相比, 光学诊疗显示出无创性和高空间选择性的优点. 有机小分子染料具有确定且易于修饰的化学结构、 良好的重现性和优异的生物相容性, 与无机和聚合物材料相比, 它是一类具有前景的可用于光学诊疗的光敏剂. 本文总结了基于传统小分子染料、 给体-受体(D-A)共轭小分子和聚集诱导发光(AIE)分子等有机小分子的纳米粒子在光学诊疗中的应用. 此外, 对于光学诊疗用有机小分子染料纳米粒子未来的挑战和前景也进行了展望.

关键词: 有机小分子纳米粒子, 光声成像, 荧光成像, 光热治疗, 光动力学治疗

Abstract:

Cancer is a global public health issue that is severely threatening human health. Efficient diagnostic and therapeutic methods are in great demand. Photosensitizer(PS)-enabled phototheranostics that integrate diagnosis and therapy into a single platform under near-infrared(NIR) laser irradiation is superior to conventional surgery resection and chemotherapy in terms of noninvasiveness, minimal harm to normal tissues, and high spatial selectivity. With the merits of defined and easily-tuned chemical structure, good reproducibility, and excellent biocompatibility, organic small molecule dyes are promising PSs in phototheranostics as compared to their inorganic and polymeric counterparts. We herein summarize the recent advances of organic small molecules, including conventional small molecule dyes, donor-acceptor(D-A) conjugated small molecules, and aggregation-induced emission molecules(AIEgens), organic small molecule nanoparticles(OSMNs) in phototheranostics. The future challenges and perspectives of OSMNs in phototheranostics are also discussed.

Key words: Organic small molecule nanoparticles, Photoacoustic imaging, Fluorescence imaging, Photothermal therapy, Photodynamic therapy

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