高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (5): 973-979.doi: 10.7503/cjcu20180811

• 物理化学 • 上一篇    下一篇

质子化非那吡啶在功能化复合介孔膜修饰的液/液界面上的转移反应

刘书峰, 邱海燕, 姜涛, 张烨桦, 赵韵, 成汉文, 陈勇()   

  1. 上海应用技术大学化学与环境工程学院, 上海 201418
  • 收稿日期:2018-12-03 出版日期:2019-04-17 发布日期:2019-04-17
  • 作者简介:

    联系人简介: 陈 勇, 男, 博士, 副教授, 主要从事复合介孔膜材料的合成及其在液/液界面电化学中的应用研究. E-mail: yongchen@sit.edu.cn

  • 基金资助:
    国家自然科学基金(批准号: 21605103, 31800830)和厦门大学固体表面物理化学国家重点实验室开放课题(批准号: 201606)资助.

Ion Transfer Behavior of Protonated Phenazopyridine at the Liquid/Liquid Interface Modified by Functionalized Hybrid Mesoporous Silica Membrane

LIU Shufeng, QIU Haiyan, JIANG Tao, ZHANG Yehua, ZHAO Yun, CHENG Hanwen, CHEN Yong*()   

  1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China
  • Received:2018-12-03 Online:2019-04-17 Published:2019-04-17
  • Contact: CHEN Yong E-mail:yongchen@sit.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.21605103, 31800830) and the Open Foundation of State Key Laboratory of Physical Chemistry of Solid Surfaces of Xiamen University, China(No.201606).

摘要:

采用循环伏安法和差分脉冲伏安法考察了临床药物盐酸非那吡啶在功能化复合介孔膜修饰的水/1,6-二氯己烷(W/DCH)界面上的转移行为. 研究结果表明, 盐酸非那吡啶中的非那吡啶(PAP) 可在酸性条件下发生质子化形成非那吡啶阳离子(HPAP+)并在该界面上发生转移. 根据循环伏安曲线峰电流与扫描速率的关系以及Randles-Sev$\check{c}$ik 方程, 计算得到HPAP+在复合介孔膜内水相中的扩散系数为5.14×10-8 cm2/s. 研究发现, 相对于空白膜修饰的W/DCH界面, 该复合介孔膜修饰的W/DCH界面可增强非那吡啶阳离子转移时的电流响应, 并提升非那吡啶阳离子的检测性能. 另外, 利用液/液界面电化学方法绘制了非那吡啶在功能化复合介孔膜修饰的W/DCH界面上的离子分布图, 从而得到非那吡啶在该界面上不同条件下的分布情况及其分配系数和吉布斯转移自由能.

关键词: 非那吡啶, 液/液界面, 电化学, 离子转移

Abstract:

The transfer behavior of a clinical drug, phenazopyridine hydrochloride, at the water/1,6-dichlorhexane(W/DCH) interface modified by functionalized mesoporous silica membrane was studied by cyclic voltammetry and differential pulse voltammetry. It was found that the phenazopyridine(PAP) can be protonated to form phenazopyridine cation(HPAP+) under acidic condition, which can transfer at such a membrane-modified W/DCH interface. According to the relationship between the transfer peak current and the scan rate, as well as the equation of Randles-Sev$\check{c}$ik, the diffusion coefficient of HPAP+ in the functionalized hybrid mesoporous silica membrane was calculated to be 5.14×10-8 cm2/s. In addition, the electrochemical response of ion-transfer of HPAP+ at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane is much higher than bare PET membrane, which can improve the electrochemical detection performance of phenazopyridine cation. Moreover, the ionic partition diagram of HPAP+ at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane was obtained by differential pulse voltammetry, which can not only understand the distribution of HPAP+ under different conditions(pH value and interfacial potential), but also obtain the distribution coefficient and ion-transfer Gibbs free energy of HPAP+, which helps to understand the transmembrane process of HPAP+ across biological membrane and provide a new electrochemical method to detect phenazopyridine hydrochloride.

Key words: Phenazopyridine, Liquid/liquid interface, Electrochemistry, Ion transfer

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