高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (1): 28-43.doi: 10.7503/cjcu20190572

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由聚合物门控的介孔二氧化硅基刺激响应性药物递送系统

王星火,汤钧(),杨英威()   

  1. 吉林大学化学学院, 纳微构筑化学国际合作联合实验室, 长春 130012
  • 收稿日期:2019-11-05 出版日期:2020-01-10 发布日期:2019-12-17
  • 通讯作者: 汤钧,杨英威 E-mail:chemjtang@jlu.edu.cn;ywyang@jlu.edu.cn
  • 基金资助:
    国家自然科学基金批准号:(51673084);国家自然科学基金批准号:(21871108);吉林省省校共建项目: 新材料专项基金资助批准号(SXGJSF2017-3)

Mesoporous Silica Nanoparticles-Based Stimuli-Responsive Drug Delivery Systems Gated by Polymers

WANG Xinghuo,TANG Jun(),YANG Yingwei()   

  1. International Joint Research Laboratory of Nano-Micro Architecture Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2019-11-05 Online:2020-01-10 Published:2019-12-17
  • Contact: Jun TANG,Yingwei YANG E-mail:chemjtang@jlu.edu.cn;ywyang@jlu.edu.cn
  • Supported by:
    ? Supported by the National Natural Science Foundation of China Nos(51673084);? Supported by the National Natural Science Foundation of China Nos(21871108);the Jilin Province-University Cooperative Construction Project: Special Funds for New Materials, China No(SXGJSF2017-3)

摘要:

本文主要介绍了以聚合物体系作为门控构筑的基于介孔二氧化硅纳米粒子的刺激响应性药物控释体系, 并根据聚合物类别将门控体系分为聚合物刷、 聚合物交联网络和聚合物包裹层三类. 根据聚合物“阀门”与无机纳米粒子的共价或非共价连接方式, 综述了这些杂化材料在不同外界刺激作用下的药物控制释放行为, 并给出该领域所面临的机遇和挑战.

关键词: 刺激响应药物递送系统, 大分子, 聚合物刷, 聚合物交联网络, 聚合物包裹层, 纳米阀门, 超分子化学, 靶向给药, 介孔二氧化硅纳米粒子

Abstract:

With the rapid development ofmaterials science and nanotechnology, stimuli-responsive drug delivery systems(DDS) for cancer therapy have drawn more and more attention. Mesoporous silica nanoparticles(MSNs) possess numerous advantages, such as large loading capacity, desirable biocompatibility, and various types of stimuli-responsiveness, which endowed them with significant roles in biomedical and related applications. Hybrid materials, particularly with MSNs as drug carriers and polymers as gatekeepers have emerged as promising DDS in recent years. In this review, we make an overview of such organic-inorganic hybrid materials for controlled drug release, with themain focus on the use of three types of polymer gating systems on the surfaces of MSNs, which include polymer brushes, polymers networks, and polymer coatings. On the basis of the types of connections, covalent or non-covalent, between these gatekeepers and drug carriers, we showcase the controlled drug release properties of these hybrid materials in response to a variety of external stimuli. The challenges and chances of hybrid nanocarriers constructed from MSNs and polymers are also discussed.

Key words: Stimuli-responsive drug delivery system, Macromolecule, Polymer brushe, Polymer crosslinked network, Polymer coating, Nanovalve, Supramolecular chemistry, Targeted drug delivery, Mesoporous silica nanoparticles

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