高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (3): 499.doi: 10.7503/cjcu20120994

• 研究论文: 无机化学 • 上一篇    下一篇

四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉的合成及结构表征

郭喜明1, 郭斌2, 陈业宏1   

  1. 1. 哈尔滨工业大学生命科学与技术学院, 哈尔滨 150001;
    2. 哈尔滨工业大学材料工程学院, 哈尔滨 150001
  • 收稿日期:2012-11-02 出版日期:2013-03-10 发布日期:2013-02-18
  • 通讯作者: 郭喜明,男,博士,副教授,主要从事纳米医药、配位化学研究.E-mail:ximing.guo@yahoo.com.cn E-mail:ximing.guo@yahoo.com.cn
  • 基金资助:

    中央高校基本科研业务费专项基金(批准号:2010012,2009003)和科技部国际合作项目(批准号:2012DFR203320)资助.

Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

GUO Xi-Ming1, GUO Bin2, CHEN Ye-Hong1   

  1. 1. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China;
    2. Shool of Materials Scince and Engineering, Harbin Institute of Technology, Harbin 150001, China
  • Received:2012-11-02 Online:2013-03-10 Published:2013-02-18
  • Contact: guo ximing E-mail:ximing.guo@yahoo.com.cn

摘要:

设计并合成了一种卟啉类光敏剂与抗癌药羟基喜树碱通过共价键相连的四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉化合物. 通过紫外光谱、 红外光谱、 核磁氢谱和质谱分析等手段对其结构进行了表征. 在癌症治疗过程中目标化合物中2种药物可能起到一定的协同效应.

关键词: 卟啉, 10-羟基喜树碱, 四对氯乙酰氧基苯基卟啉, 四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉

Abstract:

Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin was designed and synthesized through tetrahydroxy-phenylporphyrin and 10-hydroxycamptothecin(HCPT). The structure of tetra(p-aceto-10-hydroxycamptothecin)phenyl porphyrin was confirmed by UV-Vis spectra, IR spectra, 1H NMR and MALDI-TOF-MS spectra. The mass spectra were measured under different conditions via MALDI-TOF-MS and Agilent LC-MS. Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin may play a synergistic effect in threapy of cancer.

Key words: Porphyrin, 10-Hydroxycamptothecin, Tetra-p-chloroacetylphenylporphyrin, Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

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