Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (1): 65.

• Articles • Previous Articles     Next Articles

Synthesis of 2-Aroylamido-5-benzyl-1,3,4-thiadiazoles and Studies on Their Reactions with Benzaldehyde

FENG Xiao-Ming1, CHEN Rong1, HUANG Jin-Song1, ZHANG Zi-Yi2   

  1. 1. Department of Chemistry, Southiwest Normal Uniivrsity, Chongqing, 630715;
    2. Department of Chemistry, Lanzhou University
  • Received:1992-03-06 Revised:1992-06-20 Online:1993-01-24 Published:1993-01-24

Abstract: In this paper, thirteen new 2-aroylamido-5-benzyl-1, 3, 4-thiadiazoles 2a-m were synthesized by cyclization 1-phenylacetyl-4-aroylthiosemicarbazides la-m in ice acetic acid.Thirteen new 2-aroylamido-5-(1'-phenyl-2'-hydroxyphenylethyl)-l,3,4-thiadiazoles 3a-m were obtained by nucle-ophilic addition of benzyl carbanion of 2a-m with benzaldehyde in EtONa-EtOHsolution.The structures of compounds 2a-m and those of 3a-m were confirmed by elementary analysis, IR, 1H NMR, and MS.

Key words: Acylthiosemicarbazide, 1, 3, 4-Thiadiazoles, Nucleophilic addition

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