Fe3+-doped Polyaminopyrrole Nanoparticles for in situ Magnetic Resonance Imaging and Photothermal Therapy of Breast Cancer

doi:10.7503/cjcu20240156

Abstract

Abstract:

Fe³⁺-doped polyaminopyrrole nanoparticles（Fe/Ppy-NH₂ NPs） with uniform size are prepared by Fe³⁺- induced oxidative polymerization of aminopyrrole and the coordination between Fe³⁺ and polyaminopyrrole. The colloidal stability of Fe/Ppy-NH₂ NPs is good， and the mass fraction of Fe³⁺ is as high as 17.4%. On the one hand， the large amount of Fe³⁺ doping in Fe/Ppy-NH₂ NPs can enhance the extinction ability in near infrared region， and the photothermal conversion efficiency of is 37.9%， which showing that Fe/Ppy-NH₂ NPs is a good photothermal reagent for the photothermal therapy of tumors. On the other hand， the presence of single electron in the 3d orbit of Fe³⁺ can reduce the longitudinal relaxation time， Fe/Ppy-NH₂ NPs are able to act as T₁-weighted magnetic resonance imaging （MRI） contrast agents for tumor localization. In conclusion， Fe/Ppy-NH₂ NPs have shown good effects in in-situ MRI and photothermal therapy of breast cancer.

Key words: Polyaminopyrrole, Fe³⁺-doping, Magnetic resonance imaging, Photothermal therapy

CLC Number:

O631

TrendMD:

ZHU Xuanqi, CUI Liying, ZHAO Xinyu, JIANG Ling, ZHANG Xue. Fe³⁺-doped Polyaminopyrrole Nanoparticles for in situ Magnetic Resonance Imaging and Photothermal Therapy of Breast Cancer[J]. Chem. J. Chinese Universities, 2025, 46(1): 20240156.

Figures/Tables 10

References 26

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Fe³⁺-doped Polyaminopyrrole Nanoparticles for in situ Magnetic Resonance Imaging and Photothermal Therapy of Breast Cancer

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