Improvement of Endothelialization of(Heparin/Chitosan) Multilayer Films via Chemical Cross-Linking

Chem. J. Chinese Universities

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Improvement of Endothelialization of(Heparin/Chitosan) Multilayer Films via Chemical Cross-Linking

HOU Yue, LIN Quan-Kui, JI Jian^*, SHEN Jia-Cong

Key Laboratory of Macromolecule Synthesis and Functionalzation of Minster of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

Received:2008-03-10 Revised:1900-01-01 Online:2008-09-10 Published:2008-09-10
Contact: JI Jian

Abstract

Abstract: Heparin(HEP) /chitosan(CHI) multilyayer films were cross-linked by 1-ethyl-3-(3-dimethy-laminopropyl) carbodiimide(EDC) technique. The stability and endothelial cell activities of multilayer films were investigated. QCM-D test indicates that the cross-linking could improve the stablility of the multilayer films. The multilayer films had good stability when simulating human blood flow rate-3.0 cm/s. In vitro endothelial cell tests suggest that cross-linking could effectively modify the viscoelasticity of(HEP/CHI) multilayer film surface and improve the adhesion and proliferation behavior of endothelial cells. The cross-linked(HEP/CHI) multilayered film might have a great potential as a coating for cardiovascular materials.

Key words: Heparin, Chitosan, Endothelial cell, Cross-linking, Layer-by-layer self-assembly

CLC Number:

O631

TrendMD:

HOU Yue, LIN Quan-Kui, JI Jian^*, SHEN Jia-Cong. Improvement of Endothelialization of(Heparin/Chitosan) Multilayer Films via Chemical Cross-Linking[J]. Chem. J. Chinese Universities, doi: .

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Improvement of Endothelialization of(Heparin/Chitosan) Multilayer Films via Chemical Cross-Linking

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