Synthesis and Characterization of Water-soluble Zinc Porphyrin Complex and Its Interaction with CT DNA

Abstract

Abstract: A porphyrin 5,10,15,20-tetrakisporphyrin and its Zn complex(TPPBr(Zn)) were synthesized and characterized. The interaction of TPPBr(Zn) with CT DNA was studied by UV-Vis spectroscopy, fluorescence spectra, circular dichroic spectrum and viscosity measurements. The constant of TPPBr(Zn) binding to CT DNA is 2.64×10⁵ L/mol. The results suggest that the porphyrin complex can bind to DNA by self-stacked outside binding and static binding.

Key words: Water-soluble zinc porphyrin, DNA, Self-stack and static-binding

CLC Number:

O614

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KANG Jing-Wan, WU Hai-Xia, LU Xiao-Quan, SU Bi-Quan, ZHOU Lin . Synthesis and Characterization of Water-soluble Zinc Porphyrin Complex and Its Interaction with CT DNA[J]. Chem. J. Chinese Universities, 2005, 26(6): 997.

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Synthesis and Characterization of Water-soluble Zinc Porphyrin Complex and Its Interaction with CT DNA

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