Interaction Between Daunorubicin and DNA at Co Ion Implanted Modified Glass Carbon Electrode

Abstract

Abstract: With Co/GCE as the working electrode, an interaction between daunorubicin and DNA was studied. The peak current of daunorubicin decreased with increasing the concentration of DNA and then disappeared, which indicated that an unelectroactive complex of DNR with DNA was formed. The UV-Vis spectrum showed that the daunorubicin intercalated into DNA. In the presence of DNA, the electrochemical behavior of DNR was unchanged. The binding constant and binding-site size of DNR-DNA interaction were obtained by nonlinear regression analysis, to be 1.09×10⁸cm³/mol and 4, respectively. One helix in the DNA structure combined two DNR.

Key words: Daunorubicin, DNA, Ion implantation, Modified electrode, Electrochemical method

CLC Number:

O644

TrendMD:

WANG Jing, HU Jin-Bo, SHANG Jun, LI Qi-Long . Interaction Between Daunorubicin and DNA at Co Ion Implanted Modified Glass Carbon Electrode[J]. Chem. J. Chinese Universities, 2004, 25(9): 1689.

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Interaction Between Daunorubicin and DNA at Co Ion Implanted Modified Glass Carbon Electrode

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