Abstract: A novel aerodynamic force capillary microdrop-injection-chemiluminescence(AFCM-CL) system for the determination of ethamsylate was proposed in this paper. In this system the ethamsylate microdrop formed at the end of the capillary droped into the reactor cell by the force of the gravity and the high press gas automatically. Then the ethamsylate was directly oxidized by dissolved oxygen in the presence of hexacyanoferrate(Ⅲ) to generate a CL signal in sodium hydroxide medium. The phenomena of sample zone dilution and spreading disappeared as the capillary was used as the sample channel and gas pressure was used as driving force without the carrier stream. Therefore, a high sensitivity was obtained compared with the FI-CL method. The analysis sample volume is only about 8 μL and the sample throughput is 180 h^-1. The system shows that the ethamsylate is detected linearly in the mass concentration range from 5×10^-10—1×10^-6 g/mL. The detection limit is 1.4×10^-10 g/mL(1.1 pg). The relative standard deviation is 3.1% at 2.5×10^-8 g/mL(n=7).

Key words: Chemiluminescence, Capillary, Microdrop-injection, Ethamsylate