Chemical Journal of Chinese Universities ›› 2020, Vol. 41 ›› Issue (11): 2421-2425.doi: 10.7503/cjcu20200351

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Voltage Modulated Electrochemiluminescence for Highly Sensitive Detection

ZHANG Jingjing1,2, JIN Rong2, FANG Danjun1(), JIANG Dechen2()   

  1. 1.School of Pharmacy,Nanjing Medical University,Nanjing 211166,China
    2.State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China
  • Received:2020-06-15 Online:2020-11-10 Published:2020-11-06
  • Contact: FANG Danjun,JIANG Dechen;
  • Supported by:
    Supported by the National Natural Science Foundation of China(21974071)


A voltage modulated electrochemiluminescent(ECL) method is established for highly sensitive detection. In this new strategy, a small voltage is imposed at a constant voltage that could increase ECL intensity from luminol-hydrogen peroxide by ca. 2 times. This ECL intensity shows a good linear relationship with the concentration of hydrogen peroxide in the range of 1 nmol/L—200 μmol/L with a detection limit of 0.1 nmol/L(S/N=3). The results exhibit that the voltage modulated ECL could be an effective way to increase ECL intensity, and more importantly, used to study the electrochemical process at the electrode interface.

Key words: Electrochemiluminescence, Voltage modulation, Luminol, Hydrogen peroxide, Highly sensitive detection

CLC Number: