Investigation on the Interaction of β-K4H3 [SiW9O37(CpTi)3]·11H2O Polyacid Derivative with DNA

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (2): 214.

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Investigation on the Interaction of β-K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂O Polyacid Derivative with DNA

LI Jian-Xin¹, WANG Ying², WANG Xiao-Hong¹, LIU Ju-Tao¹, LI Yu-Xin², HUANG Bai-Qu², LIU Jing-Fu¹

1. Faculty of Chemistry;
2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China

Received:2002-05-27 Online:2003-02-24 Published:2003-02-24

Abstract

Abstract: The interaction between β-K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂0 and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K₄H₃[SiW₉O₃₇(CpTi)₃]·11H₂0 can degrade the genomic DNA. The treatment of plasmid DNA with β-K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂0 resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis. These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.

Key words: K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂0, Agarose gel electrophoresis, DNA

CLC Number:

O614

TrendMD:

LI Jian-Xin, WANG Ying, WANG Xiao-Hong, LIU Ju-Tao, LI Yu-Xin, HUANG Bai-Qu, LIU Jing-Fu. Investigation on the Interaction of β-K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂O Polyacid Derivative with DNA[J]. Chem. J. Chinese Universities, 2003, 24(2): 214.

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Investigation on the Interaction of β-K₄H₃ [SiW₉O₃₇(CpTi)₃]·11H₂O Polyacid Derivative with DNA

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