Abstract: Fourier transform infrared spectroscopy(FTIR) was applied to study the malignant and normal tissues of lung. The distinct differences were observed in the FTIR spectra between the normal and malignant lung tissues. Amide Ⅱ bands were weak in malignant tissues but strong in normal tissues; CHbending bands of malignant tissues around 1460cm^-1became lower than those of normal tissues; the bands around 1240 and 1080 cm^-1, related to P-Oand C-O stretching, respectively, both revealed different changes in malignant and normal tissues. The results also show that four groups of relative intensity ratios, including I₁₆₄₀/I₁₅₅₀, I₁₄₆₀/I₁₄₀₀, I₁₂₄₀/I₁₃₁₀and I₁₀₈₀/I₁₁₆₀, were used to distinguish the normal and malignant tissues. The relative intensities of I₁₆₄₀/I₁₅₅₀and I₁₀₈₀/I ₁₁₆₀of the malignant tissues were higher than that of the normal tissues; nevertheless those ratios of I₁₄₆₀/I₁₄₀₀, I₁₂₄₀/I₁₃₁₀were lower in the malignant tissues. This might indicate that the FTIRspectroscopy can be used in the clinical diagnoses.

Key words: Lung cancer, FTIR, Diagnose