Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (1): 25.

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Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes

XU Hong^1,2, DENG Hong¹, HU Hong-Yu³, LIU Jian-Zhong¹, CHAO Hui¹, LIU Jie¹, JI Liang-Nian¹

1. School of Chemistry and Chemical Enginering, Zhongshan University, Guangzhou 510275, China;
2. Normal College of Shenzhen University, Shenzhen 518060, China;
3. Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China

Received:2002-08-14 Online:2003-01-24 Published:2003-01-24

Abstract

Abstract: A new ruthenium polypyridine complex, [Ru(phen)₂(pMIP)]²⁺(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and ¹H NMR. Spectroscopic methods have been carried out on the interaction mechanism of the Ru (Ⅱ) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (Ⅱ) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.

Key words: Ruthenium(Ⅱ) polypyridine complex, RNA, Interaction

CLC Number:

O614.821

TrendMD:

XU Hong, DENG Hong, HU Hong-Yu, LIU Jian-Zhong, CHAO Hui, LIU Jie, JI Liang-Nian. Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes[J]. Chem. J. Chinese Universities, 2003, 24(1): 25.

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Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes

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