Studies on Interaction of Tetracycline-Al(Ⅲ) Complex with DNA

Abstract

Abstract: The interaction of tetracycline(TC) Al(Ⅲ) complex with DNAwas studied. DNAcould bind to calf thymus DNAwith affinity in the presence of aluminum ions, which have been confirmed by absorption and fluorescence spectra. The increase of peak intensity and red shift of tetracycline in the presence of aluminum ions showed that TC Al binary complex was formed. The spectra changes of TC Al binary complex in the presence of DNAindicate that TC Al binary complex can interact with DNAto form ternary complex with the ratio of n(Al): n(TC): n(DNA)=1:1:1. The binding constant of TC Al complex interacting with DNAwas 6.5×10⁴ L/mol. The formation of binary and ternary complexes could be affected by the pHvalue of the solution. DNAcan also be determined by TC Al binary complex interacting with DNAin the range from 1.0×10^-6 to 6.0×10⁵ mol/Lwith the detection limit of 5.0×10^-7 mol/L.

Key words: Tetracycline, Aluminum ion, Complex, DNA

CLC Number:

O657.3

TrendMD:

YANG Zhou-Sheng, YU Jun-Sheng, CHEN Hong-Yuan . Studies on Interaction of Tetracycline-Al(Ⅲ) Complex with DNA[J]. Chem. J. Chinese Universities, 2002, 23(8): 1457.

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Studies on Interaction of Tetracycline-Al(Ⅲ) Complex with DNA

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