Preparation of a New Adsorbent for Binding Low Density Lipoprotein

Abstract

Abstract: Anew adsorbent for binding low-density lipoprotein was prepared by the immobilization of sulfuric group on crosslinked poly(vinyl alcohol) bead. Spacers with different lengths were introduced, by the reaction with polyethylene polyamine, to the crosslinked poly(vinyl alcohol) bead with epoxy group, and then sulfuric group was immobilized by the reaction with DMF/ClSO₃H. It was found that this method could increase the amount of immobilized sulfuric group, which increased with decreasing crosslinking degree and increasing PVAconcentration. The adsorption experiments in vitro showed that this kind of adsorbent had a satisfactory adsorption capacity and selectivity.

Key words: Low density lipoprotein, Adsorption, Indole-3-acetic acid, Tryptophan, Macroporous PVA beads, Poly(vinyl alcohol), Sulfonation, Spacer arm, Low density lipoprotein

CLC Number:

O647

TrendMD:

XU Jian-Kuan, HE Bing-Lin . Preparation of a New Adsorbent for Binding Low Density Lipoprotein[J]. Chem. J. Chinese Universities, 2002, 23(7): 1421.

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Preparation of a New Adsorbent for Binding Low Density Lipoprotein

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