Existence States and Activities of ZnPcSP as Photosensitizer Against Cancer in Solutions

Abstract

Abstract: The sulfonated phthalimidomethyl phthalocyanine Zinc(ZnPcSP) is an amphiphilic photosensitizer against cancer. The characteristic absorption peak of monomer and aggregate of ZnPcSP were observed, and the effects of solution compositions on its aggregation were investigated. In 70% MeOH/H₂O, 70% EtOH/H₂O, 50% EtOH/H₂O, 70% i-PrOH/H₂O, 70% CH₂OHCHOHCH₃/H₂O, 50% DMSO/H₂O, 50% DMF/H₂O(volume fraction) and CEL solutions, ZnPcSP existed in the equilibrium between monomer and dimer, the dimerization constants were 1.314×10⁵, 8.496×10⁴, 9.753×10⁴, 5.583×10⁴, 3.809×10⁵, 4.430×10³, 8.679×10³ mol/L, respectively. But trimerization of ZnPcSP took place in water and saline solution, and trimerization constants were 1.296×10⁸ and 2.236×10⁸ mol^-2·L ² respectively. Furthermore, the effect of existence states of ZnPcSP on the activities against S₁₈₀ carcinoma were estimated. The result showed that the inhibitory rate of ZnPcSP(3.1×10^-6 mol/L) in CEL solution mainly existing in the form of monomer was about 8 times higher than that of ZnPcSP in saline solution mainly existing in the form of trimer.

Key words: Amphiphilic phthalocyanines, Photosensitizer against cancer, Aggregation state, Electronic absorption spectrum, Activity

CLC Number:

O641.4

TrendMD:

HUANG Jian-Dong, LIU Er-Sheng, YANG Su-Ling, XUE Jin-Ping, CHEN Nai-Sheng, HUANG Jin-Ling . Existence States and Activities of ZnPcSP as Photosensitizer Against Cancer in Solutions[J]. Chem. J. Chinese Universities, 2002, 23(12): 2287.

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Existence States and Activities of ZnPcSP as Photosensitizer Against Cancer in Solutions

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