Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (9): 1395.

• Articles • Previous Articles     Next Articles

The First Total Synthesis of (±)-Sinaiticin

SHE Xue-Gong, GU Wen-Xin, JING Xiao-Bi, PAN Xin-Fu    

  1. College of Chemistry and Chemical Engineering, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:1999-10-12 Online:2000-09-24 Published:2000-09-24

Abstract: (±)-Sinaiticin was first synthesized by nine steps in 13.4% overall yield. In this approach the conversion of cis-6 to trans-7 by epimerization and the oxidative cyclization reaction are the key steps.

Key words: (±)-Sinaiticin, Coupling, Epimerization, Total synthesis

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