Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (7): 1063.

• Articles • Previous Articles     Next Articles

Studies on the Reaction Between Ciprofloxacin and Bovine Serum Albumin

ZHANG Xiao-Wei, ZHAO Feng-Lin, LI Ke-An   

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871
  • Received:1999-01-24 Online:1999-07-24 Published:1999-07-24

Abstract: In this paper, the study of the reaction between Ciprofloxacin(CPFX) and bovine serum albumin(BSA) at different pHis reported. The conformational change of BSA due to the addition of CPFX is discussed. It is proved that only dynamic quenching exits between CPFX and BSA. Quenching constant is obtained and the distance between CPFX and BSA is determined according to the theory of energy transfer.

Key words: Ciprofloxacin, Bovine serum albumin, Fluorescence quenching

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