Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (12): 1850.

• Articles • Previous Articles     Next Articles

Studies on Stereoselectivity in Tris(phenanthroline) Nickel(Ⅱ) Binding to DNA

SONG Yu-Min, KANG Jing-Wan, WANG Zhi-Hua, LU Xiao-Quan, GAO Jin-Zhang   

  1. Department of Chemistry, Northwest Normal University, Lanzhou 730070, China
  • Received:1999-02-11 Online:1999-12-24 Published:1999-12-24

Abstract: Binding of Δ-, Λ-[Ni(phen)3]2+to calf thymus DNAwas studied by circular dichroism and electrochemical methods. The selectivity of Δ isomer in binding to a right-handed duplex of DNAwas found. Binding constants and binding site sizes for Δ-and Λ-[Ni(phen)3]2+with DNAwere determined from voltammetric data.

Key words: Nickel, Phenanthroline, DNA

CLC Number: 

TrendMD: