A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran

Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (1): 65.

• Articles • Previous Articles Next Articles

A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran

SHI Hong-Xin¹, LIN Hui², Bloch R.³, Mandvill G.³

1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014;
2. Central Laboratory of Biochemistry & Physiological Sciences, Zhejiang Medical University, Hangzhou, 310006;
3. Lab. des Carbocycles, I. C. M. O. Uniuersite de Paris-Sud, 91405 Orsay Cedex, France

Received:1996-12-02 Online:1998-01-24 Published:1998-01-24

Abstract

Abstract: A novel approach to synthesize trans-2,5-diaryltetrahydrofuran is described. The new antagonists of PAF are obtained by six step reactions of arylation, oxidation, arylation,cyclization, hot decomposition and hydrogenation starting from (±)4,10-dioxatricyclo [5, 2, 1, 0^2,6]-dec-8-ene-3-ole is described. Three title compounds (8a-8c) are synthesized.

Key words: Diaryltetrahydrofuran, Antagonist, Synthesis, Chiral, Stereoselectivity

CLC Number:

O641.6

TrendMD:

SHI Hong-Xin, LIN Hui, Bloch R., Mandvill G.. A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran[J]. Chem. J. Chinese Universities, 1998, 19(1): 65.

[1]	CAO Shujie, LI Hongjun, GUAN Wenli, REN Mengtian, ZHOU Chuanzheng. Progress on the Stereocontrolled Synthesis of Phosphorothioate Oligonucleotides [J]. Chem. J. Chinese Universities, 2022, 43(Album-4): 20220304.
[2]	YAO Qing, YU Zhiyong, HUANG Xiaoqing. Progress in Synthesis and Energy-related Electrocatalysis of Single-atom Catalysts [J]. Chem. J. Chinese Universities, 2022, 43(9): 20220323.
[3]	WANG Ruyue, WEI Hehe, HUANG Kai, WU Hui. Freezing Synthesis for Single Atom Materials [J]. Chem. J. Chinese Universities, 2022, 43(9): 20220428.
[4]	WEI Chunhong, JIANG Qian, WANG Panpan, JIANG Chengfa, LIU Yuefeng. Atomic Scale Investigation of Pt Atoms/clusters Promoted Co-catalyzed Fischer-Tropsch Synthesis [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220074.
[5]	HUANG Qiuhong, LI Wenjun, LI Xin. Organocatalytic Enantioselective Mannich-type Addition of 5H-Oxazol-4-ones to Isatin Derived Ketimines [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220131.
[6]	JIN Ruiming, MU Xiaoqing, XU Yan. Bio-chemical Synthesis of Melanin Precursor—— 5，6-Dihydroxyindole（DHI） [J]. Chem. J. Chinese Universities, 2022, 43(8): 20220134.
[7]	ZHANG Xinxin, XU Di, WANG Yanqiu, HONG Xinlin, LIU Guoliang, YANG Hengquan. Effect of Mn Promoter on CuFe-based Catalysts for CO₂ Hydrogenation to Higher Alcohols [J]. Chem. J. Chinese Universities, 2022, 43(7): 20220187.
[8]	ZHOU Zixuan, YANG Haiyan, SUN Yuhan, GAO Peng. Recent Progress in Heterogeneous Catalysts for the Hydrogenation of Carbon Dioxide to Methanol [J]. Chem. J. Chinese Universities, 2022, 43(7): 20220235.
[9]	LI Yidi, TIAN Xiaochun, LI Junpeng, CHEN Lixiang, ZHAO Feng. Electron Transfer on the Semiconductor-microbe Interface and Its Environmental Application [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220089.
[10]	LU Cong, LI Zhenhua, LIU Jinlu, HUA Jia, LI Guanghua, SHI Zhan, FENG Shouhua. Synthesis， Structure and Fluorescence Detection Properties of a New Lanthanide Metal-Organic Framework Material [J]. Chem. J. Chinese Universities, 2022, 43(6): 20220037.
[11]	ZHUANG Jiahao, WANG Dingsheng. Current Advances and Future Challenges of Single-atom Catalysis [J]. Chem. J. Chinese Universities, 2022, 43(5): 20220043.
[12]	FENG Li, SHAO Lanxing, LI Sijun, QUAN Wenxuan, ZHUANG Jinliang. Synthesis of Ultrathin Sm-MOF Nanosheets and Their Visible-light Induced Photodegradation of Mustard Simulant [J]. Chem. J. Chinese Universities, 2022, 43(4): 20210867.
[13]	ZHANG Zhinan, CHENG Haiming, TENG Shiyong, ZHANG Ying. Synthesis and Optical Properties of RbPb₂Cl₅ [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220418.
[14]	QIN Gaizhao, TANG Minghua, LAI Yalin, YUAN Liming. Chiral Metal-organic Cage MOC-PA as a Chiral Stationary Phase for Capillary Electrophoresis [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220417.
[15]	XING Peiqi, LU Tong, LI Guanghua, WANG Liyan. Controllable Syntheses of Two Cd（II） Metal-organic Frameworks Possessing Related Structures [J]. Chem. J. Chinese Universities, 2022, 43(10): 20220218.

A Novel Approach to Synthesize trans-2,5-Diaryltetrahydrofuran

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments