Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (8): 1259.

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A Study of the Interaction Between Titanocene Glycine Complex and DNA

ZHANG Zhi-Gang1, YANG Pin2   

  1. 1. Institute of Molecular Science, Nanjing University, Nanjing, 210093;
    2. Dept.of Chem., State Key Lab. of Coordination Chem., Shanxi University, Taiyuan, 030006
  • Received:1996-07-23 Online:1997-08-24 Published:1997-08-24

Abstract: The interaction between titanocene glycine complex and DNAhas been investigat-ed by UV-Vis spectra and fluorescence probe method. The results suggest that the complex forms an irreversible adduct with DNAin molar ratio 1:1, and induces the comformation changes of DNAat high ratio of the complex to DNA,leading to the disruption of DNAdu-plexical structure.

Key words: Titanocene glycine complex, Antitumor, DNA

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