Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (9): 1345.

• Articles • Previous Articles     Next Articles

Studies on the Mechanism of the Chiral Metal Complexes with DNA by Fluorimetry Method

JIN Lan1, YANG Pin2, LI Qing-Shan1   

  1. 1. Coordination Chemistry Institute of Nanjing University, Nanjing, 210093;
    2. Inslitute of Molecular Science, Shanxi University, Taiyuan, 030006
  • Received:1995-09-11 Online:1996-09-24 Published:1996-09-24

Abstract: The fluorescence characteristics of EBwhich is sensitive to DNAwas used as a probe to study the interaction of [Ni(phen)3]2+,[Fe(phen)3]2+ with DNA.The results show that the complexes bind to DNAby two models, one is the partial insertion of one of the ligands between the base pairs on the DNAduplex strand, the other is electrostatic binding by which the complexes can interact electrostatically with the phosphate backbone of DNA.

Key words: Chiral metal complexes, DNA, EB probe

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