Molecular Mechanisms of DNA Recognition by RuNi Heterobinuclear Complexes

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (7): 1064.

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Molecular Mechanisms of DNA Recognition by RuNi Heterobinuclear Complexes

BU Xian-He¹, ZHU Shu-Mei², YANG Ming², WANG Kui²

1. Department of Chemistry, Nankai University, Tianjin, 300071;
2. State Key Lab. of Natural and Biomimetic Drugs, Beijing Med. Univ., Beijing

Received:1995-01-07 Revised:1995-04-03 Online:1995-07-24 Published:1995-07-24

Abstract

Abstract: The interactions of a new class of intelligent RuNi heterobinuclear complexes, which have been found to be potent inhibitors of HIV-Ireplication, with DNA having been studied. The complexes bind to DNA by intercalation based on increment in viscosity on titration with CT-DNA. The binding strength was further evaluated by spectroscopic measurements. Gel electrophoresis reveals the conversion of supercooled pBR322 DNA to the nicked form and linear form, which is induced by the Ru part of the complexes.

Key words: RuNi heterobinuclear complex, DNA, Recognition

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BU Xian-He, ZHU Shu-Mei, YANG Ming, WANG Kui. Molecular Mechanisms of DNA Recognition by RuNi Heterobinuclear Complexes[J]. Chem. J. Chinese Universities, 1995, 16(7): 1064.

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Molecular Mechanisms of DNA Recognition by RuNi Heterobinuclear Complexes

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