The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (3): 410.

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The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA

WANG Zi-Chun, HUANG Deng-Yu, YUAN Jing-Ming

Institute of Molecular Science, Shanxi University, Taiyuan, 030006

Received:1994-03-25 Revised:1994-12-20 Online:1995-03-24 Published:1995-03-24

Abstract

Abstract: Pingyangmycin is an antitumor antibiotics. The therapeutic activity is to degrade template DNA or interfer DNAbiosynthesis. It is necessary for the degradation of DNA to have O₂and a metal ion. However,the effect of divalent metal ions on the interaction between Pingyangmycin and DNA is quite different from those of various ions. In this paper, we reported the effect of Fe²⁺, Co²⁺, Cu²⁺, Zn²⁺and Mg²⁺etc. on DNA clevaged by Pingyangmycin with agarose electrophoresis and CDspectra. The results showed that the degradation of DNAin the presence of Pingyangmycin was obviously increased by Fe²⁺or Co²⁺and inhibited by Cu²⁺, Zn²⁺or Mg²⁺. Meanwhile, the possible mechanism of the two kinds of divalent metal ions for the interaction between Pingyangmycin and DNA was also discussed.

Key words: Divalent metal ions, Pingyangmycin, DNA, Interaction

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WANG Zi-Chun, HUANG Deng-Yu, YUAN Jing-Ming. The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA[J]. Chem. J. Chinese Universities, 1995, 16(3): 410.

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The Effect of Divalent Metal Inos on the Interaction Between Pingyangmycin and DNA

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