Determination of the Inclusion Interaction Between β-Cyclodextrin and Bilirubin

Abstract

Abstract: In this paper, a kind of cyclic oligosaccharides, β-cyclodextrin was found to possess inclusion ability with bilirubin which is a metabolite of heme in senescent red blood cells.The structure of inclusion complex of β-cyclodextrin/bilirubin was determined by UVvisible spectra and X-ray powder diagrams. Experimental results indicate that 2 moles of β-cyclodextrin include one mole bilirubin to form the inclusion complex by van der Waals' force, hydrophobic interaction and hydrogen bonds.

Key words: Cyclodextrin, Bilirubin, Inclusion interaction, Cyclic oligosacchride, Inclusion complex

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ZHAO Xiao-Bin, HE Bing-Lin. Determination of the Inclusion Interaction Between β-Cyclodextrin and Bilirubin[J]. Chem. J. Chinese Universities, 1994, 15(8): 1250.

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Determination of the Inclusion Interaction Between β-Cyclodextrin and Bilirubin

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