Synthesis and Antitumor Activity of Cyclopentadienyl Titanium(Ⅳ),Zirconium(Ⅳ) Fluorouracil Complexes

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (8): 1119.

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Synthesis and Antitumor Activity of Cyclopentadienyl Titanium(Ⅳ),Zirconium(Ⅳ) Fluorouracil Complexes

AI Hai-Ma¹, ZHOU Yao-Kun², ZHOU Mei-Hua³

1. Laboratory of Synthetic Rubber Factory, Yanshan Petrochemical Company, Beijing, 102503;
2. Department of Chemictry, Lanzhou University, Lanzhou, 730000;
3. Department of Bioiogy, Lanzhou University, Lanzhou

Received:1993-09-04 Revised:1994-02-01 Online:1994-08-24 Published:1994-08-24

Abstract

Abstract: Twenty of the 5-fluorouracil titanium(Ⅳ), zirconium(Ⅳ)complexes of type(RCp)M(Opm)₂Cl, (RCp)₂M(Opm)Cl and (RCp)Ti(Opm)Cl₂(OPm=(19940804-1119-1.jpg)X=O, S) have been prepared by the reaction of dichloro bis(cyclopentadinyl)or(methylcyclopentadinyl)titanium and zirconium and trichlorocyclopentaclinyl or methylcy-clopentadienyl titanium with 2-methoxy-5-fluorouracil and 2-methylthio-5-fluorouracil, which have antitumor activities respectively in toluene at 110 ℃.All the complexes have been characterized by elementary analysis, ¹H NMRand IRspectra.The antitumor activities against Ehrlich ascites carcinoma in mice were observed.

Key words: Cyclopentadinene, Fluorouracil, Titanium, Biological activity, Anticarcinogen

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AI Hai-Ma, ZHOU Yao-Kun, ZHOU Mei-Hua. Synthesis and Antitumor Activity of Cyclopentadienyl Titanium(Ⅳ),Zirconium(Ⅳ) Fluorouracil Complexes[J]. Chem. J. Chinese Universities, 1994, 15(8): 1119.

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Synthesis and Antitumor Activity of Cyclopentadienyl Titanium(Ⅳ),Zirconium(Ⅳ) Fluorouracil Complexes

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