Stereoselectivity in Chiral Complex Tris(phenanthroline) Iron (Ⅱ)Binding to DNA

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (12): 1742.

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Stereoselectivity in Chiral Complex Tris(phenanthroline) Iron (Ⅱ)Binding to DNA

YANG Pin, JIN Lan, YANG Bin-Sheng

Institute of Molecular Science, Shanxi University, Taiyuan, 030006

Received:1993-12-18 Revised:1994-06-30 Online:1994-12-24 Published:1994-12-24

Abstract

Abstract: The chiral complexes tris (phenanthroline) iron (Ⅱ) were synthesized. The structures of the complexes were determined by IR, UV, EXAFS, CD. The binding of the complexes to calf thymus DNAwas studied by spectral methods. Hypochromism and enhancement of luminescence accompany DNAbinding and the binding show the characteristic of intercalation. The enhancement of luminescence seen for △ isomer in the presence of DNAis greater than that for ∧ isomer. The luminescence quenchng produced by [Fe(CN)₆]^4- for △ isomer in the presence of DNAis smaller than that for Aisomer. It means that △isomer binds preferentially to B-DNA.

Key words: Chiral metal complex, DNA, Stereoselectivity

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YANG Pin, JIN Lan, YANG Bin-Sheng. Stereoselectivity in Chiral Complex Tris(phenanthroline) Iron (Ⅱ)Binding to DNA[J]. Chem. J. Chinese Universities, 1994, 15(12): 1742.

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Stereoselectivity in Chiral Complex Tris(phenanthroline) Iron (Ⅱ)Binding to DNA

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