Chem. J. Chinese Universities ›› 1991, Vol. 12 ›› Issue (4): 464.

• Articles • Previous Articles     Next Articles

Fluorescence Method for Screening Anticancer Drugs

Zhang Kai-cheng, Chen Jiang-hua, Li Zhi-liang   

  1. Department of Chemistry and Chemical Engineering, Hman University, Changsha, 410082
  • Received:1989-10-23 Online:1991-04-24 Published:1991-04-24

Abstract: Anew method for screening anticancer drugs is proposed. Ethidium bromide(EthBr),a fluorescent dye, can insert into the double helix chains of DNA and increase the intensity of fluorescence. So do some drugs. When this drug is added to the EthBr-DNA fluorescent system, the fluorescence intensity will be decreased. We find that the drug which van decrease 50% in fluorescent intensity of EthBr-DNA system can act with tumour. The fluorescence method is in accordance with the test of S-180 in mice and has more reliability than the methylene blue test.

Key words: Anticancer drugs, Fluorescence method, Complex

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